Phospho atm

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August undefined, 2024

WebPE anti-ATM Phospho (Ser1981) Antibody. Etoposide-treated, HeLa cells were treated with FOXP3 Fix/Perm Buffer Set and then intracellularly stained with anti-human/mouse ATM Phospho (Ser1981) (clone 10H11.E12) PE (filled histogram). Open histogram represents the staining with untreated HeLa cells. WebHuman Phospho-ATM (S1981) Antibody Summary Species Reactivity Human Specificity Detects human ATM when phosphorylated at S1981. Source Recombinant Monoclonal Rabbit IgG Clone # 1163B Purification Protein A or G purified from cell culture supernatant Immunogen Phosphopeptide containing the human ATM S1981 site Formulation

Prognostic Significance of Nuclear Phospho-ATM Expression in

WebApr 12, 2024 · Osimertinib is a third-generation epidermal growth factor receptor and tyrosine kinase inhibitor (EGFR-TKI) approved for the treatment of lung adenocarcinoma patients harboring EGFR mutations. However, acquired resistance to this targeted therapy is inevitable, leading to disease relapse within a few years. Therefore, understanding the … WebAug 14, 2015 · Phospho-ATM (p-ATM) plays a key role in the activation of DNA repair and several oncogenic pathways as well as in the maintenance of genomic integrity. The … flags that are the same

Phospho-ATM (Ser1981) Monoclonal Antibody (C.70.6)

WebAtaxia-telangiectasia Mutated (ATM) is a protein that belongs to the PI3/PI4 kinase family. Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and an increased risk of lymphoid cancer. WebATM phosphorylates proteins instead of lipid and has many downstream targets that act as cell-cycle regulators including: P53, Mdm2, BRCA1, and SMC1. The ATM protein is … WebDec 30, 2016 · p-Atm Antibody (10H11.E12) is a mouse monoclonal IgG 1 κ, cited in 118 publications, provided at 200 µg/ml raised against a synthetic phosphopeptide … canon pixma ts3150 handbuch deutsch

Phospho-ATM (Ser1981) (10H11.E12) Mouse mAb #4526

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WebThe phosphorylation of H2AX can be detected by Western blotting or immunofluorescence, revealing the frequency of DSBs. The phosphatidylinositol 3-kinases have been implicated in H2AX phosphorylation, but it is unclear if ATM is the primary H2AX kinase or if other members of the family such as DNA-PK and ATR contribute in a similar manner. WebJan 5, 2024 · Ataxia-telangiectasia mutated (ATM) regulates the DNA damage response as well as DNA double-strand break repair through homologous recombination. Here we show that ATM is hyperactive when the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is chemically inhibited or when the DNA-PKcs gene is deleted in human cells. canon pixma ts3150 druckkopfausrichtungWebAnti-phospho-ATM (Ser1981) Antibody, clone 10H11.E12, Ascites Free is an antibody against phospho-ATM for use in Immunocytochemistry, Immunoprecipitation, ELISA, Western Blotting. - Find MSDS or SDS, a COA, data sheets and more information. flags that begin with a

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Phospho atm

WebImmunogen Description A synthesized peptide derived from human Phospho-ATM (S1981) Alternative Names kinase ATM; Serine-protein kinase ATM; Accession No. Uniprot:Q13315; Uniprot Q13315; Calculated MW 370kDa; Storage Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4˚C short term. WebMar 22, 2024 · a, Western blot analysis of phospho-ATM/ATR substrates (S*Q) in EPCAM +, EPCAM − and EPCAM − Rhoj KO cells untreated, treated with cisplatin/5FU for 8 h and treated with cisplatin/5FU for 8 h followed by 16 h of ATM inhibitor (KU60019, 5μM) or ATR inhibitor (VE-821, 1μM) or a combination of ATM and ATR inhibitor showing the specific ...

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WebAll lanes : Anti-ATM (phospho S1981) antibody [10H11.E12] (ab36810) at 10 µg/ml Lane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : Extract from … WebATM phosphorylates proteins instead of lipid and has many downstream targets that act as cell-cycle regulators including: P53, Mdm2, BRCA1, and SMC1. The ATM protein is responsible for repairing double-stranded DNA breaks that occur because of ionizing radiation and other mutagens.

WebAnti-ATM phospho S1981 Monoclonal Antibody is directed against human ATM and is useful in determining its presence in various assays. This monoclonal anti-ATM antibody … WebAffordable TaqMan Assays for All of Your qPCR Needs

Webphospho-: Prefix for O- phosphono-, which may replace the suffix phosphate; for example, glucose phosphate is O- phosphonoglucose or phosphoglucose. See also: phosph- , … WebJan 20, 2015 · Using this antibody, we showed that phospho-Y370 level was decreased when Flag-tagged Y370F but not WT ATM was co-immunoprecipitated with Myc-tagged EGFR (Supplementary information, Figure S4B).

WebPhospho-ATM (Ser1981) Antibody (MA5-15185) in ICC/IF. Immunofluorescence analysis of Phospho-ATM (Ser1981) was performed using 70% confluent log phase HeLa cells treated with 10 uM Etoposide for 2 hours. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA …

WebThe meaning of PHOSPH- is phosphorus. How to use phosph- in a sentence. canon pixma ts3150 connect to laptopWebFigure Legend Snippet: The expression levels of phospho-ATM (Ser1981), phospho-Chk2 (Thr68), and p21 in the exposed cells were higher than those in the sham-exposed cells at the indicated times. β-actin was used as a loading control. All proteins were determined in whole cell lysates from the sham and exposed HaCaT cells after the indicated exposure … flags that are similar to the us flagWebAug 14, 2015 · Phospho-ATM (p-ATM) plays a key role in the activation of DNA repair and several oncogenic pathways as well as in the maintenance of genomic integrity. The present study was therefore performed to understand the significance of p-ATM in melanoma progression and to correlate it with patient prognosis. canon pixma ts3150 opnieuw installerenWebThe phospho-ATM-NEMO-Akt-mTOR signalosome localizes to the mitochondria and is essential for the PARP-inhibition-mediated cytoprotective effects in oxidatively stressed … flags that are white and redWebPhospho-ATM/ATR Substrate Motif (S*Q) (D23H2/D69H5) MultiMab™ Rabbit mAb mix recognizes peptides and proteins containing sequences of phospho-Ser followed by Gln at the +1 position. The antibody does not cross-react with corresponding non-phosphorylated sequences or with other phospho-Ser containing motifs. Species Reactivity: All Species … canon pixma ts3150 einrichtenWebATM phosphorylates proteins instead of lipid and has many downstream targets that act as cell-cycle regulators including: P53, Mdm2, BRCA1, and SMC1. The ATM protein is responsible for repairing double-stranded DNA breaks that occur because of ionizing radiation and other mutagens. canon pixma ts3150 media marktWebPhospho- (Ser/Thr) ATM/ATR Substrate (4F7) Rabbit mAb detects endogenous levels of proteins containing the ATM/ATR substrate motif. This antibody preferentially binds peptides and proteins that contain phospho-Ser/Thr preceded by Leu or similar hydrophobic amino acids at the -1 position and followed by Gln at the +1 position. canon pixma ts3150 installation wifi