Web29 jan. 2024 · Recurrent mutations in splicing factor 3B subunit 1 (SF3B1) have been identified in several malignancies and are associated with an increased expression of 3’ cryptic transcripts as a result of alternative branchpoint recognition. A large fraction of cryptic transcripts associated with SF3B1 mutations is expected to be sensitive for RNA … WebThe SF3B1- mutation is characterised by ring sideroblasts (erythroblasts with iron-loaded mitochondria), ineffective erythropoiesis and an indolent clinical course. SF3B1-mutation Approximately half of MDS-patients carries a somatic mutation in a spliceosome-gene.
MYH7 Gene - Somatic Mutations in Cancer - Wellcome Sanger …
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MYC Mutation - My Cancer Genome
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