WebApr 3, 2024 · Cell division cycle 20 (Cdc20) is a crucial regulator of cell division, with its critical function being the activation of the anaphase-promoting complex (APC/C) [10,11,12,13,14,15,16]. The APC complex is associated with Cdc20 and Cdc20 homologue 1 (Cdh1), sequentially, leading to binding and ubiquitination of target proteins for … WebCell division cycle 20 (CDC20) encodes a regulatory protein interacting with the anaphase-promoting complex/cyclosome (APC/C) in the cell cycle and plays important roles in tumorigenesis and progression of multiple tumors. The present study aimed to investigate the clinical significance of CDC20 in …
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The cell division cycle protein 20 homolog is an essential regulator of cell division that is encoded by the CDC20 gene in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex (APC/C), a large 11-13 subunit complex that initiates chromatid … See more CDC20, along with a handful of other Cdc proteins, was discovered in the early 1970s when Hartwell and colleagues made cell-division cycle mutants that failed to complete major events in the cell cycle in the yeast strain S. … See more CDC20 is a protein related to the beta subunit of heterotrimeric G proteins. Near its C-terminus it contains seven WD40 repeats, which are multiple short, structural motifs of … See more The APC/C complex regulates itself so that it is present during the appropriate times of the cell cycle. In order for CDC20 to bind the APC/C, specific APC/C subunits must be phosphorylated by Cdk1 (among other Cdks). Therefore, when cdk activity is high in … See more CDC20 is also a part of, and regulated by, the spindle assembly checkpoint (SAC). This checkpoint ensures that anaphase proceeds only … See more CDC20 has been shown to interact with: • ANAPC7 • BUB1B, • CDC16, • CDC27, • Cyclin A1, See more CDC20-homologue 1 (Cdh1) plays a complementary role to CDC20 in cell cycle progression. During the time of APC/C activity, Cdh1 is phosphorylated and cannot bind to the APC/C. After metaphase, however, S/M-Cdks are inactivated by … See more CDC20 is often elevated in cancerous tissues for multiple kinds of cancer. It is correlated with aggressiveness in breast cancer: higher … See more WebJul 25, 2024 · The higher number of gene isoforms and divergence of functions of certain SAC proteins such as BUB3, MAD1, MAD2, and Monopolar Spindle 1 (MPS1) in plants … dog vomit and diarrhea and shaking
CDC20, a potential cancer therapeutic target, is negatively regulated ...
WebJun 29, 2024 · From the proof-of-principle work on human cancer tissue cells, p31 comet and APC/C Cdc20 are currently suggested to be the two best candidates to try and … WebFeb 25, 2016 · The mitotic checkpoint complex (MCC) inhibits the anaphase-promoting complex (APC/C) bound to Cdc20 in response to spindle defects. Here, the authors show that Bub1-Plk1-mediated phosphorylation ... WebJan 19, 2009 · The anaphase promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase playing essential functions in mitosis. It is conserved from yeast to human and relies on two adaptor proteins, … dog vomit foam yellow