Cytostatic compounds
WebDec 19, 2013 · Cytostatic compounds are an emerging group of environmental contaminants whose presence, effects, and risk are highly unknown. Cytostatic compounds are a heterogeneous group of pharmaceuticals used to treat cancer and other diseases that act inhibiting cell division and hence the development of tumours (Villasana … WebNational Center for Biotechnology Information
Cytostatic compounds
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WebSep 25, 2024 · Background Drug screening for the identification of compounds with anticancer activity is commonly performed using cell lines cultured under normal oxygen pressure and physiological pH. However, solid tumors are characterized by a microenvironment with limited access to nutrients, reduced oxygen supply and acidosis. … WebCompound; Antibiotics: Sulfamethoxazole Trimethoprim Erythromycin Norfloxacin Ofloxacin Oxytetracycline Sulphonamides Tetracycline: Beta-blockers and other cardiovascular …
WebFeb 8, 2013 · Cytostatic compounds were measured using ultra performance liquid chromatography connected to a triple quadrupole detector (TqDetector, Acquity Waters, USA) (UPLC–MS/MS). Several LC columns were used to separate target compounds and Luna C18 (150 mm × 2 mm ID, particle size 5 μm, Phenomenex, Torrance, USA) was … WebNov 18, 2024 · The use of targeted cytostatic drugs started in the late 1990s for treatment of breast cancer , against which cytostatics are still commonly used . Currently, cytostatics are rarer than cytotoxic drugs: a recent high-throughput study found 2327 cytostatic-only compounds in a total of 388,000 compounds screened .
WebNov 6, 2024 · The following work provides a perspective on the degradation of cytostatic pollutants through TiO2 heterogeneous photocatalysis. Cytostatic drugs are emerging pollutants used for cancer treatment found in hospital and domestic wastewater. Small amounts of cytostatic pollutants may pose severe health problems in human beings, … WebFeb 20, 2024 · As test compounds, four substances that are being used for chemotherapeutic treatment of cancer (doxorubicin, vinblastine, mitomycin C) or can …
WebApr 14, 2024 · Cytostatic compounds are an important group of micro-pollutants since they are used to kill cells or stop cell division. For this reason, they are also considered … chromium family projectsWebApr 14, 2024 · Cytostatic compounds are an important group of micro-pollutants since they are used to kill cells or stop cell division. For this reason, they are also considered mutagenic. Several cytostatic compounds have been detected in hospital effluents, in the influents and effluents of wastewater treatment plants and even in river water. However, … chromium factsWebAug 5, 2024 · Guidelines are in place to assure limited occupational exposure to cytostatic drugs. Even though this has led to a reduction in exposure, several studies reported quantifiable concentrations of these compounds in healthcare workers. In this study, we evaluated occupational exposure to cytostatic drugs in hospital workers from the … chromium favorites locationWebFive human ovarian cancer cell lines (UWB1.289, UWB1.289+BRCA1, SK-OV-3, OVCAR-3, and OVCAR-5) were treated with the newly synthesized compounds at concentrations of 1–100 μΜ in order to test their cytostatic and cytotoxic activity. chromium familyWebMay 10, 2016 · Broad-acting cytostatic compounds exhibit selective toxic responses that can be linked to protein expression signatures. Next, we focused on the compounds that exhibited broad cytostatic effects on all or most of the cell lines. Among these agents, highly heterogeneous effects on cytotoxicity were discovered in the TNBC cell lines (Fig. … chromium family elementWebNational Center for Biotechnology Information chromium feature requestWebApr 11, 2024 · The discovery of cisplatin has influenced scientists to study the anticancer properties of other metal complexes. Organotin(IV) dithiocarbamate compounds are gaining attention as anticancer agents due to their potent cytotoxic properties on cancer cells. In this study, a series of organotin compounds were assessed for their toxic … chromium fat burner